Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds

Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds

Blood Test 83% Effective in Detecting Colon Cancer

Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds

Clinical Trial Reveals 83% Effective Blood Test for Colorectal Cancer Detection

Colorectal cancer, a formidable health challenge, is on the rise. Yet, recent advancements offer hope. A groundbreaking blood test, developed by Guardant Health, demonstrates 83% accuracy in detecting this deadly disease. This revolutionary development, published in the New England Journal of Medicine, could change the landscape of cancer screening, making it less invasive and more accessible.


Colorectal cancer ranks as the third most common cancer among men and women in the United States. According to the American Cancer Society, over 50,000 people are projected to die from this disease in 2024. Early detection is crucial, but traditional screening methods like colonoscopies and fecal tests deter many from getting tested. Guardant Health’s innovative blood test could be the game-changer needed to improve early detection rates and save lives.

The Breakthrough Blood Test

What Makes It Unique?

Guardant Health’s Shield blood test offers a non-invasive alternative to traditional screening methods. This test detects 83% of colorectal cancer cases with a specificity of 90%. Such accuracy, combined with the convenience of a simple blood draw, promises to increase screening adherence.

How Does It Work?

The test analyzes cell-free DNA (cfDNA) in the blood to detect cancerous cells. This method targets specific genetic markers associated with colorectal cancer, providing reliable results without the need for invasive procedures.

Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds

Clinical Trial Insights

Guardant Health conducted the ECLIPSE study, enrolling over 20,000 participants aged 45-84 across the U.S. The study’s primary outcomes focused on sensitivity for colorectal cancer and specificity for advanced neoplasia. The results were promising:

  • 83% sensitivity in detecting colorectal cancer
  • 88% sensitivity for pathology-confirmed Stages I-III
  • Stage-specific sensitivity: 65% for Stage I, 100% for Stages II and III

Expert Opinions

Dr. William M. Grady, a molecular biologist and gastroenterologist, noted, “The results of the study are a promising step toward developing more convenient tools to detect colorectal cancer early while it is more easily treated.” Dr. Barbara H. Jung, President of the American Gastroenterological Association, added, “Having a blood draw versus undergoing an invasive test will reach more people. My hope is that with more tools, we can reach more people.”

Comparing Screening Methods


  • Invasive: Requires bowel preparation and sedation.
  • Thorough: Can detect and remove polyps.
  • Frequency: Recommended every 10 years for average-risk individuals.

Fecal Tests

  • Non-invasive: Requires at-home stool collection.
  • Effective: Good sensitivity for detecting blood in stool.
  • Frequency: Annually or biennially, depending on the test.

Blood Tests

  • Non-invasive: Simple blood draw.
  • Convenient: Easier for patients to adhere to regular testing.
  • Effective: High sensitivity and specificity for cancer detection.

Implications for Public Health

Encouraging Regular Screening

Regular screening is vital for early detection and treatment of colorectal cancer. The less invasive nature of blood tests could increase screening rates among those who avoid traditional methods.

Potential for Reduced Mortality

Early detection of colorectal cancer significantly improves treatment outcomes. The Shield blood test’s high accuracy rate could lead to earlier interventions, reducing mortality rates.

Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds

Patient Perspectives

Patients often avoid colonoscopies due to the preparation and discomfort involved. Fecal tests, while non-invasive, are seen as unpleasant. The Shield blood test offers a hassle-free alternative, potentially increasing compliance.


  • John D., 52: “I always dreaded colonoscopies. The blood test was quick and painless. I feel more at ease knowing I can screen regularly without the discomfort.”
  • Linda M., 47: “Collecting stool samples was embarrassing. The blood test is a dignified alternative. I’m more likely to keep up with my screenings now.”

Future Prospects

Expansion to Other Cancers

The success of the Shield test opens doors for developing similar blood tests for other cancers, potentially revolutionizing cancer screening across the board.

Integration with Existing Practices

While the blood test is a significant advancement, it is essential to integrate it with existing screening practices. Colonoscopies will still play a crucial role in detecting and removing polyps, preventing cancer from developing.

Ongoing Research

Continued research and development are necessary to improve the accuracy and applicability of blood tests for cancer screening. Guardant Health’s ongoing studies aim to refine their methods and expand their offerings.

Blood Test Detects Colon Cancer with 83% Accuracy, Study Finds


Q: How accurate is the Shield blood test for colorectal cancer?

A: The Shield blood test detects colorectal cancer with 83% sensitivity and 90% specificity.

Q: Will colonoscopies still be needed?

A: Yes, colonoscopies are still essential for detecting and removing polyps, which can prevent cancer.

Q: How often should I get screened with the blood test?

A: The recommended frequency for blood tests is still being determined. Consult your healthcare provider for personalized advice.

Q: Is the blood test covered by insurance?

A: Coverage may vary. Check with your insurance provider for details on your specific plan.

Q: Can the blood test detect other types of cancer?

A: Currently, the Shield test is designed for colorectal cancer. Research is ongoing to develop similar tests for other cancers.

Key Takeaways

  • Guardant Health’s Shield blood test shows 83% accuracy in detecting colorectal cancer.
  • The test offers a non-invasive alternative to traditional screening methods.
  • Increased screening adherence could significantly reduce colorectal cancer mortality rates.
  • Continued research and integration with existing practices are crucial for broader implementation.


The development of the Shield blood test marks a significant advancement in colorectal cancer screening. By offering a less invasive and more convenient option, it has the potential to increase screening rates and save lives. As research continues and the test becomes more widely available, the hope is that it will become a standard part of cancer screening protocols, making early detection accessible to more people.

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