Less pancreatic cells may lead to Diabetes: Study.


Beat Diabetes by Subtyping Beta Cells: Revolutionary Research

According to a new study conducted by Weill Cornell Medicine researchers, losing high-functioning cluster 1 beta cells in the pancreas may contribute to the development of type 2 diabetes. This discovery revolutionizes our understanding of how beta cells operate and provides crucial insights into how we should subtype beta cells in order to treat or prevent diabetes.

Subtype Beta Cells: A Game-Changing Approach to Diabetes Treatment

Before Weill Cornell Medicine’s investigation, people believed that all beta cells were created equal, and would simply count total beta cells. This new research illuminates the importance of subtyping beta cells to get a clear understanding of their functions, and the potential benefits of creating treatment plans based on individual subtype functions.

The study examined both mouse and human beta cells and found that cluster 1 beta cells have unique gene expression signatures which include the high expression of genes that help mitochondria break down sugar, power insulin secretion, and allow for better sugar metabolism.

Weill Cornell Medicine researchers recommend subtyping all β-cells carefully and focusing on the roles of these special cluster 1 β-cells when researching diabetes.

The Most High-Functioning Beta Cells: Cluster 1 Beta Cells

Cluster 1 beta cells are highly productive beta cells that have a unique gene expression signature. Compared with other beta cell types, they are better at metabolizing sugar and producing insulin. Such high productivity is a positive sign of cluster 1 beta cells ability to carry out the bulk of the workload for insulin production in the pancreas. Therefore, their loss can have profound impacts and may contribute to the development of type 2 diabetes.

Tracking Cluster 1 Beta Cells and their Relationship to Diabetes

To track cluster 1 beta cells, Weill Cornell Medicine researchers used a methodology called single-cell transcriptomics, which measures all the genes expressed in individual mouse beta cells, grouping them into four types. High CD63 beta cells were then distinguished from the other low CD63 beta cell types. The high CD63 gene expression provides a way to identify the cells without destroying them, and CD63 protein marks the specific beta cell subtype.

Further research is necessary to determine what happens to high CD63-producing beta cells in mice with diabetes and discover how to keep them from disappearing. Weill Cornell Medicine researchers also aim to examine how GLP-1 agonists affect all beta cell types, and may be a way to get low CD63 producing beta cells to work better. Scientists may use this new information to create a better treatment plan to help patients with diabetes.

Implications for Beta Cell Transplants

The discovery also has important implications for the use of beta cell transplants to treat diabetes. Transplanting beta cells with high CD63 production into mice with type 2 diabetes restored their blood sugar levels to normal. Conversely, removing the transplanted cells caused high blood sugar levels to return. Transplanting low CD63 production beta cells into the mice didn’t restore blood sugar to normal levels. The transplanted low CD63 beta cells instead appeared dysfunctional. These results indicate that it may be better to transplant only high CD63- beta cells, and it might also be possible to transplant fewer of these highly productive cells.


In conclusion, the subtyping of beta cells, especially cluster 1 beta cells, is the revolutionary approach we needed to understand how beta cells work and the potential treatment options for diabetes. The loss of highly productive beta cells, as shown in Weill Cornell Medicine’s research, can have a profound impact, perhaps even contributing to the development of type 2 diabetes. Nonetheless, the discovery of CD63 expression and subtyping of beta cells shows great potential for better treatment of diabetes. It may lead to the development of ways to prevent or treat type 2 diabetes using highly productive beta cells such as cluster 1 beta cells, and with this knowledge, we can make significant strides in the way we treat diabetes.#Loss #productive #pancreatic #cells #contribute #Diabetes #Study #Health

Like it? Share with your friends!


What's Your Reaction?

hate hate
confused confused
fail fail
fun fun
geeky geeky
love love
lol lol
omg omg
win win


Choose A Format
Voting to make decisions or determine opinions
Formatted Text with Embeds and Visuals
Youtube and Vimeo Embeds
Soundcloud or Mixcloud Embeds
Photo or GIF
GIF format